Publications
Recent Publications
The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis
Highlights
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We have elucidated a novel interaction between the formin, DAAM1 and the deubiquitinase, USP10.
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DAAM1 binds to and inhibits USP10’s DUB activity through the FH2 domain of DAAM1 independent of its actin functions.
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DAAM1 inhibition of USP10’s DUB activity subsequently affects integrin protein levels and integrin and matrix cell surface recycling.
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The USP10/DAAM1 axis regulates integrin homeostasis that is important for a myriad of cellular processes.
Phillips AT, Boumil EF, Castro N, Venkatesan A, Gallo E, Adams JJ, Sidhu SS, Bernstein AM (2021). USP10 Promotes Fibronectin Recycling, Secretion, and Organization
Our data suggest that reduced integrin degradation with a subsequent increase in integrin/FN recycling after wounding may be a newly identified mechanism for the characteristic accumulation of ECM in corneal scar tissue.
PRESENTATIONS
Nicholas Mueller, Arunkumar Venkatesan, Audrey M Bernstein (2023) CYP39A1 Protein Structure Abnormalities Correspond to Altered Enzymatic Activity in Exfoliation Glaucoma, Biomedical Sciences, SUNY Upstate, Syracuse, NY
Tilstra-Smith, A. Christine, Jacob, Swathi, Castro, Nileyma, Williams, Tere, Bernstein, Audrey M. (2023) Reenerative healing immune response after chemical burn, Biomedical Sciences, SUNY Upstate, Syracuse, NY
Jose Quiroz,Tere M Williams, Audrey M. Bernstein, Avnish Deobhakta (2023) Engineered bispecific antibodies as potential immune modulating therapies for uveitic glaucoma Meeting: ARVO, Investigative Ophthalmology and Visual Science
J Mario Wolosin, Zheng Wang, and Audrey M Bernstein (2022) SMAD2/3 activation and myofibroblast conversion of corneal fibroblasts is fully dependent on the activation of MELK by the noncanonical TGFβ1 pathway. EVER Congress, Valencia, Spain.
